| Sunday, Sep. 21, 2008 | |||
| Arizona Cardinals at Washington Redskins | |||
 21 | Cardinals QB Kurt Warner looks like the guy who won two MVPs in St. Louis. Warner will have to stay poised in the pocket against a Redskins defense that put pressure on Saints QB Drew Brees last week. Redskins RB Clinton Portis will test a Cardinals defense that played well against the run last week. Result: Washington Redskins 24, Arizona Cardinals 17 | ||
 20 | |||
| Houston Texans at Tennessee Titans | |||
 24 | Titans QB Kerry Collins, who has played well while Vince Young gets healthy. Collins should have success against a Texans defense that has struggled to rush the passer. Texans QB Matt Schaub is off to a rough start and could struggle against a Titans defense that has played well, but must limit the penalties. Result: Tennessee Titans 31, Houston Texans 12 | ||
 19 | |||
| Cincinnati Bengals at NY Giants Giants | |||
 28 | Bengals QB Carson Palmer has struggled in the first two games and could be in for a long day against a Giants defense that puts constant pressure on the quarerback. Giants QB Eli Manning is becoming more confidence with each game and should have success against a Bengals defense that only got one sack last week. Result: NY Giants Giants 26, Cincinnati Bengals 23 | ||
 17 | |||
| Miami Dolphins at New England Patriots | |||
 26 | Dolphins RBs Ricky Williams and Ronnie Brown will test a Patriots defense that gave up 104 yards to the Jets, but was able to stop Thomas Jones on three attempts near the goal line. Patriots QB Matt Cassel was efficient in his first NFL start and could have success against a Dolphins defense that allowed QB Kurt Warner to post a perfect 158.3 passer rating. Result: New England Patriots 13, Miami Dolphins 38 | ||
 13 | |||
| Carolina Panthers at Minnesota Vikings | |||
 21 | The Panthers have had success running the ball, but now that WR Steve Smith is back after a two-game suspension, expect the team to attack the Vikings' defense through the air . Vikings RB Adrian Peterson continues to prove his standout rookie season was no fluke. The Vikings need better play from Tarvaris Jackson if they want to win. Result: Minnesota Vikings 20, Carolina Panthers 10 | ||
 20 | |||
| Tampa Bay Buccaneers at Chicago Bears | |||
 20 | Bucs RB Earnest Graham has 207 yards on 25 carries in two games this season. Graham faces a Bears defense that played well for the first half, but rookie Jonathan Stewart rushed for 76 second-half yards. Bears rookie RB Matt Forte could struggle against a Buccaneers defense that held Michael Turner to 42 yards on the ground. Result: Chicago Bears 24, Tampa Bay Buccaneers 27 | ||
 17 | |||
| Oakland Raiders at Buffalo Bills | |||
 20 | Raiders RB Darren McFadden faces a Bills defense that held Jacksonville to 98 yards on the ground. Bills QB Trent Edwards had the most accurate game last week, when he completed 80 percent of his passes. Edwards could struggle this week against a Raiders defense that recorded five sacks last week. Result: Buffalo Bills 24, Oakland Raiders 23 | ||
 14 | |||
| Kansas City Chiefs at Atlanta Falcons | |||
 21 | The Chiefs' offense struggled last week, but things could turn around against a Falcons defense that had some mental breakdowns. Falcons QB Matt Ryan faces a Chiefs pass defense that wasn't really tested last week. The Chiefs' defense gave up 300 rushing yards to the Raiders. Result: Atlanta Falcons 38, Kansas City Chiefs 14 | ||
 19 | |||
| St. Louis Rams at Seattle Seahawks | |||
 23 | Rams QB Marc Bulger was sacked six times and passed for just 177 yards last week. Bulger should have more success against a Seahawks defense that couldn't stop QB J.T. O'Sullivan from throwing for 321 yards. Seahawks QB Matt Hasselbeck hopes to improve this week after he completed just 50 percent of his passes last week. Result: Seattle Seahawks 37, St. Louis Rams 13 | ||
 17 | |||
| Detroit Lions at San Francisco 49ers | |||
 24 | Last week, Lions QB Jon Kitna struggled when the game was on the line, which led to three interceptions in about a three-minute span. Kitna could struggle against a 49ers defense that left Matt Hasselbeck with a passer rating of 42.5. 49ers QB J.T. O'Sullivan should have success against a Lions defense that struggles against the pass. Result: San Francisco 49ers 31, Detroit Lions 13 | ||
 20 | |||
| New Orleans Saints at Denver Broncos | |||
 31 | Saints QB Drew Brees could have success against the Broncos' secondary, which gives up huge gains. Broncos QB Jay Cutler faces a Saints secondary that has been plagued by injuries. The Saints' defense had a tough time keeping Redskins QB Jason Campbell in check last week. Result: Denver Broncos 34, New Orleans Saints 32 | ||
 24 | |||
| Pittsburgh Steelers at Philadelphia Eagles | |||
 24 | Steelers QB Ben Roethlisberger has been efficient, even in bad weather. Roethlisberger faces an Eagles defense that couldn't put pressure on the quarterback and got picked apart by Tony Romo. Eagles QB Donovan McNabb could struggle against a Steelers defense that had two interceptions, two sacks and kept Derek Anderson from throwing a touchdown. Result: Pittsburgh Steelers 6, Philadelphia Eagles 15 | ||
 23 | |||
| Jacksonville Jaguars at Indianapolis Colts | |||
 26 | The Jaguars rushed for only 98 yards last week and 32 of those came on six David Garrard runs. Jaguars RB Fred Taylor should have more success against a Colts defense that gave up 180 yards to Adrian Peterson. Colts QB Peyton Manning should have success against a Jaguars defense that allowed Trent Edwards to complete 20 of 25 passes for 239 yards and a touchdown. Result: Indianapolis Colts 21, Jacksonville Jaguars 23 | ||
 20 | |||
| Cleveland Browns at Baltimore Ravens | |||
 20 | The Browns couldn't run the ball against Pittsburgh last week. Browns RB Jamal Lewis could struggle against a Ravens run defense that has been one of the best over the past decade. Rookie QB Joe Flacco faces a Browns defense that played better last week than in the opener, but there is still a lot to improve on. Result: Baltimore Ravens 28, Cleveland Browns 10 | ||
 17 | |||
| Dallas Cowboys at Green Bay Packers | |||
 28 | Cowboys QB Tony Romo could struggle against a Packers defense that used a mix of four-man rushes and blitzes, which led to five sacks against the Lions. Packers QB Aaron Rodgers faces a Cowboys defense that struggled last week, but made two sacks when it mattered to preserve the victory. Result: Green Bay Packers 16, Dallas Cowboys 27 | ||
 26 | |||
| Monday, Sep. 22, 2008 | |||
| NY Jets Jets at San Diego Chargers | |||
 28 | Jets RB Thomas Jones netted zero yards on three consecutive carries from the Patriots' 3-yard line in the second quarter last week. Jones could have more success against a Chargers defense that gave up nearly 145 rushing yards. Chargers QB Philip Rivers could have success against a Jets defense that couldn't stop the screens to WR Wes Welker and RB Kevin Faulk last week. Result: San Diego Chargers 48, NY Jets Jets 29 | ||
 20 | |||
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